Tirz 75 (High-Mass) | Dual-Agonist Ligand | CAS 2023788-19-2 | Profound Aminos

TECHNICAL SPECIFICATIONS

• Product Ref : Tirz 75 (High-Mass Reagent)
• Chemical Class : Dual-Agonist Peptide Ligand
• CAS Number : 2023788-19-2
• Molecular Formula : C₂₂₅H₃₄₈N₄₈O₆₈
• Molecular Weight : ~4813.53 g/mol
• Sequence Length : 39 Amino Acids
• Format : Lyophilized Filtered Cake
• Mass Format : High-Mass Unit (75)
• Purity : ≥99% (RP-HPLC Verified)
• Solubility : Soluble in BAC Water / Buffer
• Storage : -20°C (Desiccated)

Disclaimer : For Research Use Only (RUO). Not for human use.

Product Overview

This product comprises a High-Mass Unit (75 Format) of the synthetic peptide ligand known as Tirz. It is a linear 39-amino acid chain that functions as a Dual-Agonist, targeting two distinct incretin receptor pathways simultaneously.

Unlike standard low-mass units often limited to single-assay use, this High-Mass Format is engineered for high-throughput laboratories. It allows researchers to create a concentrated Stock Solution, ensuring that every cellular culture or study model in a study receives an identical chemical concentration.

Research Mechanism: In 2026-era metabolic research, this ligand is utilized to study:

1. Synergistic Signaling : How activating the GIP receptor alongside the GLP-1 receptor alters cellular energy homeostasis.
2. Lipid Substrate Utilization : Investigating how dual-pathway modulation influences adipocyte (fat cell) metabolism in vitro.
3. Receptor Kinetics : Measuring binding affinity without the interference of insulinogenic feedback loops.
4. Synergistic Mechanism of Action : Distinct from mono-target ligands, Tirz exhibits simultaneous affinity for both GIP and GLP-1 recognition sites. This dual-receptor occupancy modulates intracellular cAMP flux, facilitating the investigation of synergistic signaling pathways in isolated cell cultures.”

Chemical Diagram

Chemical Diagram of Tirz 75

High-resolution 2D molecular structure of Tirz 75 (CAS 2023788-19-2), illustrating its peptide backbone and lipid modification. Supplied as a lyophilized reagent vial for stock solution preparation in receptor affinity and metabolic research applications.

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Chemical structure of Tirz 75, a high-mass lyophilized reagent used as a GIP/GLP-1 receptor affinity ligand in laboratory research.

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Tirz 75 High-Mass Lyophilized Reagent Vial for Stock Solution – GIP/GLP-1 Receptor Affinity Ligand – CAS 2023788-19-2

Regulatory Status : Research Use Only (RUO). Not intended for use in humans or animals, diagnostic, or clinical use.

Comparative Research Context :

2026 Receptor Ligand Landscape

WHY SOURCE FROM PROFOUND AMINOS

1. The “Single-Stock” Advantage

Experimental error often occurs when researchers pool multiple small units together. Our Tirz 75 Format allows you to reconstitute one large volume of reagent. This ensures homogeneity (uniformity) across your entire experiment, significantly improving data reproducibility (R-Squared values).

2. Cold-Chain Integrity

Peptide ligands are sensitive to thermal degradation. We utilize a strictly monitored Cold-Chain Logistics protocol within the USA. Your reagent travels from a climate-controlled facility directly to your research facility”, preventing the breakdown often seen in non-domestic shipments.

3. Sequence Integrity Verification
Many generic sources offer high purity but broken peptide chains. We verify Peptide Integrity via Mass Spectrometry to ensure the full 39-amino acid sequence is intact and capable of binding to both target receptors.

REGULATORY & COMPLIANCE STATEMENT (RUO)

Regulatory Classification & Usage Disclaimer :

This product is strictly classified as a Research Use Only (RUO) reagent.

Chemical Reference Standard: It is supplied solely for in-vitro testing and laboratory calibration.

Not a Drug : This compound has not been evaluated by the FDA for safety or efficacy in humans.

Handling Protocol : This reagent is a potent biological modulator. Researchers must wear appropriate PPE (gloves, eyewear) during reconstitution and handling.

Safety Data : Refer to CAS 2023788-19-2 safety sheets before use.

Strict Prohibition : Any intent to use this product for bodily introduction (injection/ingestion) is a violation of federal compliance protocols.

Frequently Asked Questions

Q1: Is this product intended for human use?

A: NO. This is strictly a Chemical Reference Material for laboratory research. It is not a sterile pharmaceutical product and is not approved for human consumption or therapeutic application.

Q2: What does “75 Format” mean?

A: This refers to the Total Mass of the active lyophilized powder inside the container. It is designed for preparing large-volume stock solutions for multiple experiments.

Q3: How do I dissolve the lyophilized cake?

A: The reagent is soluble in BAC Water or a sterile buffer solution. Researchers must calculate the molarity required for their specific assay before adding solvent.

Q4: Does this ligand display cross-reactivity with Tyrosine Kinase vectors?

A: High Selectivity Profile. Structural binding assays confirm that Tirz is highly selective for G-Protein Coupled Receptors (GPCRs). It displays negligible binding affinity for the Tyrosine Kinase family, allowing researchers to isolate incretin signaling pathways without interference from divergent metabolic cascades.

Q5: Why is the powder quantity visually small?

A: The lyophilization process removes all moisture, leaving a dense “cake” at the bottom. The visual volume may vary, but the Mass Content is gravimetrically guaranteed.

Q6: Does this ligand interact with Nuclear Receptors?

A: No. This is a Peptide-Based Agonist. It targets extracellular G-Protein Coupled Receptors (GPCRs) and does not share chemical properties with cholesterol-derived scaffolds or intracellular signaling agents.

Q7: What is the shelf life?

A: In its lyophilized (powder) state, it is stable for 24 months if stored at -20°C. Once dissolved in a solvent, it should be used immediately or frozen.

Q8: Do you provide a COA?

A: Yes. Every batch includes a Certificate of Analysis verifying ≥99% purity and identity confirmation via HPLC and Mass Spectrometry.

Q9: Can this be used for “Biohacking”?

A: Absolutely Not. Any reference to personal use, biohacking, or lifestyle improvement violates our Terms of Service and will result in the cancellation of the order.

Q10: What are the storage conditions for this research reagent?

A: Store lyophilized powder at −20°C, desiccated and protected from light. All handling requirements are governed exclusively by the supplier Certificate of Analysis and institutional SOPs.