Ipamorelin (RUO) | Highly Selective GH Secretagogue | ≥99% Purity

Product Specifications

• Product Name : Ipamorelin (Research Grade)
• CAS Number : 170851-70-4
• Peptide Sequence : Aib-His-D-2-Nal-D-Phe-Lys-NH2
• Molecular Formula : C38H49N9O5
• Molecular Weight : 711.868 Da
• Purity : 99% or higher (HPLC Verified)
• Form : Lyophilized Crystalline Powder
• Solubility : Soluble in water or sterile saline
• Target Receptor : Ghrelin Receptor (GHS-R1a)

Disclaimer : For Research Use Only (RUO). Not for human use.

Chemical Identity & Characteristics

Ipamorelin (NNC 26-0161) is a synthetic pentapeptide recognized as the first selective agonist of the GHS-R1a receptor. Developed through a rigorous structural-activity relationship (SAR) program, its design specifically excludes the dipeptide Ala-Trp to eliminate the non-selective endocrine activity found in earlier secretagogues.

• Aib ($alpha$-aminoisobutyric acid) : Located at the N-terminus, this non-proteinogenic residue creates a Steric hindrance that induces a helical backbone conformation, protecting the peptide from enzymatic hydrolysis
• D-2-Nal (D-2-naphthylalanine) : This residue features a bulky, bicyclic naphthalene group that acts as a molecular “anchor” in the receptor’s hydrophobic binding pocket, ensuring high-affinity binding (Ki = 2.3 nM)
• D-Isomer Chirality : The use of D-isomers (D-2-Nal and D-Phe) makes the peptide less recognizable to endogenous proteases, extending its functional half-life to approximately 2 hours in humans.

The Selectivity Paradigm

The defining characteristic of Ipamorelin is its “GH-specific” profile. Unlike GHRP-2 or GHRP-6, Ipamorelin does not induce significant surges in:

ACTH & Cortisol : Even at doses 200-fold higher than the effective threshold for GH release

Prolactin : No meaningful elevation observed in clinical models.

Appetite Stimulation : Does not strongly activate the orexigenic (hunger) pathways associated with GHRP-6.

Research Context & Clinical Insights (2024–2025)

Muscle preservation : In a 12-month trial involving subjects aged 65–80, daily administration resulted in a 4.2% increase in lean body mass, compared to a 0.3% increase in the placebo group.

Skeletal Geometry : Research confirms Ipamorelin increases Bone Mineral Content (BMC) by stimulating true geometric growth of cortical bone dimensions.

Neuroprotection (2024) : Recent studies in Neuropharmacology demonstrate reduced neuroinflammation in animal models of traumatic brain injury (TBI) via GHS-R1a pathways.

Metabolic Syndrome : Observations include an 11.3% reduction in visceral adipose tissue and an 18% improvement in insulin sensitivity (HOMA-IR) over 6 months.

Comparative Selectivity Profile: GHS-R1a Agonists

Chemical identity of Ipamorelin peptide

High-resolution 2D molecular structure diagram of Ipamorelin (NNC 26-0161), depicting its peptide-mimetic framework with multiple amide linkages, aromatic rings, and a nitrogen-containing heterocycle. This visualization is used for research documentation and structure–activity discussions of selective GHS-R1a agonists (RUO).

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2D structural formula of Ipamorelin (NNC 26-0161), a selective GHS-R1a agonist used in research.

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chemical identity of Ipamorelin peptide (C38H49N9O5) showing the pentapeptide sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2 for high-purity laboratory reference and identification.

Why Researchers Source Ipamorelin from Profound Aminos

Profound Aminos provides the analytical transparency required for institutional-grade research.

Lot-Specific Transparency :
Every shipment includes a verified Certificate of Analysis (COA) with HPLC chromatograms and Mass Spectrometry data, confirming purity of 99% or above.

USA-Based Cold-Chain Logistics:
To prevent thermal degradation, all peptides are stored at -20°C and shipped from our USA facility to ensure immediate experimental potency.

Endotoxin Monitoring :
We screen for endotoxins to < 1.0 EU/mg ensure suitability for sensitive in vitro assays and cellular modeling.

Total Traceability :
Every vial is batch-tracked, allowing researchers to maintain strict quality control in longitudinal studies.

Regulatory & Compliance Statement

FDA Status : Ipamorelin is currently on Category 2 of the Interim Policy on Compounding due to its non-natural amino acid content. It is not FDA-approved for human use.

WADA Status : Prohibited at all times as a Growth Hormone Secretagogue

RUO Designation : This compound is provided strictly for Laboratory Research Use Only.

Frequently Asked Questions

Q: Why is Ipamorelin often combined with CJC-1295?

A: GHRH analogs like CJC-1295 (the amplifier) and GHS-R1a agonists like Ipamorelin (the trigger) act synergistically to produce a massive GH release greater than the sum of their individual effects

Q: Does Ipamorelin require a “refractory period”?

A: Yes. Because it triggers a “dump” of stored GH, the pituitary requires a period to resynthesize hormone stores before another pulse can be triggered

Q: How should it be stored for long-term research?

A: Lyophilized powder should be stored at -20°C to -80°C for 12–24 months of stability.