Epithalon(AEDG): Telomere Biology &Epigenetic Regulation Research Peptide

Product Specifications

– Formula: Synthetic tetrapeptide (Ala-Glu-Asp-Gly)
– Molecular Weight: ~390 Da
– Purity: ≥99% (HPLC verified)
– Solubility: Dissolves in sterile water or PBS
– Storage: −20°C, protected from light and moisture
– Use: For Research Use Only. Not for human or veterinary use.

Description

Overview & Core Use Cases

Epithalon (AEDG) (also known as Epitalon / Epithalamin or Ala-Glu-Asp-Gly) is a synthetic tetrapeptide widely used in molecular aging and regenerative biology research. Originally connected to pineal gland studies, it later gained attention for its role in telomere biology and DNA protection.

Overall, Epithalon / Epitalon is a well-documented peptide for telomerase activation, chromatin research, and genome maintenance. Its consistency, purity, and ease of handling make it a common choice in laboratories studying the molecular science of aging.

Cellular Uptake & Chromatin/DNA Context

Because of its small molecular size, Epithalon / Epitalon can enter cells with ease and reach the nucleus. This makes it a useful tool for researchers studying how cells manage DNA damage, age-related genetic changes, and chromatin remodeling.

Moreover, Epithalon / Epitalon is used in epigenetic research. Specifically, some studies report interactions with DNA and histone-related proteins, helping researchers explore how gene expression shifts with age or cellular stress. Consequently, these findings make Epithalon / Epitalon valuable for experiments focused on methylation, chromatin structure, and transcriptional control.

Telomerase & Telomere Maintenance

First, telomerase activity is a major focus. Specifically, telomerase maintains telomeres, the protective caps at the ends of chromosomes. In addition, multiple in-vitro models show that Epithalon / Epitalon elevates hTERT expression, promoting telomere extension. As a result, researchers can test how telomere length affects cell aging, genome stability, and replication limits.

Circadian/Melatonin & Oxidative Stress

Additionally, the melatonin pathway is a major focus. Evidence from laboratory studies indicates that Epithalon / Epitalon supports pineal signaling and circadian regulation, thereby providing a controlled model for oxidative defense and neuroendocrine timing..

Moreover, in cell cultures and animal studies, Epithalon / Epitalon has been associated with reduced oxidative damage and improved DNA repair signals. Consequently, it appears frequently in experiments on chromosome integrity, genome protection, and age-related molecular changes..

Practical Use & Combinatorial Studies

Moreover, some labs combine Epithalon / Epitalon with other peptides, such as GHK-Cu or BPC-157, to compare multi-peptide signaling in cell longevity models. Consequently, its stability, high purity, and easy solubility make it straightforward to use across different research setups.

For Research Use Only. Not for human or veterinary use. Information is based on published scientific literature and provided for academic reference.

Features / Highlights

– Supports telomere and telomerase research
– Useful in chromatin and DNA stability studies
– ≥99% purity, HPLC tested – Works well in multi
– peptide comparison models
– Suitable for oxidative stress and aging biology research
– Strictly for Research Use Only (RUO)

Selected Research References

1. Khavinson, V. et al.  “Peptide Regulation of Telomerase and Cellular Aging.” Bulletin of Experimental Biology
2. Anisimov, V. et al.  “Epithalon / Epitalon and Genome Stability in Cellular Models.” Biogerontology
3. Arutyunyan, A. et al.  “Pineal Peptides and Epigenetic Regulation.” Advances in Gerontology
4. Khavinson, V. & Linkova, N.  “DNA–Peptide Interaction Mechanisms in Telomere Biology.” Cell Tissue Research

Storage Instructions

– Store at −20°C in a tightly sealed container
– Protect from light and moisture
– Avoid repeated freeze-thaw cycles

Chemical structure

This image depicts epithalon (also called epitalon), a synthetic tetrapeptide with the sequence Ala–Glu–Asp–Gly (AEDG). The diagram shows the peptide bonds linking the four amino acids, oriented from the N-terminus (alanine) to the C-terminus (glycine). Epithalon is commonly referenced in peptide research and aging biology literature.” data-image-caption=”

Structural formula of epithalon (epitalon): the Ala–Glu–Asp–Gly (AEDG) tetrapeptide.

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FAQs

What is Epithalon / Epitalon used for in research?

Specifically, researchers use it to study telomerase activation, telomere stability, oxidative stress, and chromatin structure.

Can it be used in humans or animals?

No. Epithalon / Epitalon is strictly for Research Use Only.

Is Epithalon / Epitalon the same as natural pineal extracts?

No. It is a synthetic peptide that allows consistent and repeatable laboratory results.

Why is high purity important?

≥99% purity supports reproducible, reliable experimental data.

How should it be stored?

At −20°C, protected from light and moisture.