Acetyl Octapeptide-3 (SNAP-8) – Laboratory Research Reagent

TECHNICAL SPECIFICATIONS

• Product Ref : Acetyl Octapeptide-3 (Research Reagent)
• IUPAC / INCI Name : Acetyl Octapeptide-3
• Chemical Class : Synthetic peptide / Signal-modulating octapeptide
• Chemical Sequence : Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
• CAS Number : 868844-74-0
• Molecular Weight : ~889 g/mol
• Amino Acid Count : 8 amino acids (Octapeptide)
• Purity Standard : ≥99% (HPLC verified); MS identity confirmed; COA available on request
• Storage : Lyophilized: 2–8°C in sealed research unit
• Storage After Reconstitution : Store at −20°C according to laboratory protocol; single-use aliquots recommended
• Shelf Life : 24 months from manufacture date when lyophilized, sealed, and stored at −20°C
• Classification : Research Use Only (RUO) — Not for therapeutic, diagnostic, cosmetic, dietary, or human-application use.

Disclaimer : For Research Use Only (RUO). Not for human use.

Product Description

Overview :

Acetyl Octapeptide-3 is an eight-amino-acid synthetic peptide and a structurally extended iteration of cetyl Hexapeptide-8. In laboratory-based research, it is

studied for its competitive relationship with the N-terminal fragment of endogenous SNAP-25 (Synaptosomal-Associated Protein, 25 kDa) within the SNARE complex. These molecular interactions are the subject of ongoing in-vitro investigation (PMC7662462).

Research Mechanism :

In 2026-era research, this octapeptide reference compound is utilized to study:

SNARE Complex Interaction Assays: Investigating how the peptide competes with SNAP-25 fragments within the SNARE complex in cell-free “laboratory-based conditions using established biochemical binding assays (PMC7662462).

Vesicle-Fusion Signaling Research: Measuring signaling modulation associated with vesicle-fusion pathways at defined laboratory concentrations.

Delivery Efficiency Engineering: Evaluating stratum corneum permeation efficiency using dissolving microneedle (DMN) technology delivery models (Raphas Co., 2021).

Dual-Pathway Assay Studies: Investigating combined in-vitro interactions alongside complementary peptide reference compounds, such as Pentapeptide-18, in multi-pathway signaling models (PMC7662462).

Chemical Diagram

Chemical Diagram of Acetyl Octapeptide-3 (SNAP-8)

Acetyl Octapeptide-3 (SNAP-8) lyophilized research reagent. Formulated strictly for laboratory investigations and non-clinical research applications.

High-resolution 2D molecular diagram of Acetyl Octapeptide-3 (SNAP-8) illustrating its peptide sequence and chemical bonds. SNAP-8 is a synthetic octapeptide used as a laboratory research reagent in SNARE-complex signaling and peptide interaction studies.

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Chemical structure of Acetyl Octapeptide-3 (SNAP-8), a synthetic octapeptide studied in SNARE-complex signaling and peptide research.

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Acetyl Octapeptide-3 (SNAP-8) high-purity laboratory research reagent for SNARE complex signaling assays

Regulatory Status : Research Use Only (RUO). Not for human consumption, diagnostic, or clinical use.

Comparative Research Context :

Table 1: 2026 Neuropeptide Research Landscape

WHY SOURCE FROM PROFOUND AMINOS

1. Delivery Engineering Research Documentation We provide detailed summaries on device-enabled delivery systems, including dissolving microneedle (DMN) platforms, to address limited permeation efficiency in passive topical delivery research models. Published data suggest DMN delivery can improve stratum corneum permeation efficiency by up to 40-fold versus passive application in controlled laboratory conditions.

2. Independent Identity Verification Our research documentation is supported by laboratory-verified analytical benchmarks. Per published comparative assay data (PMC7662462), Acetyl Octapeptide-3 demonstrates enhanced molecular stability versus Acetyl Hexapeptide-8 at equivalent laboratory concentrations.

3. Regulatory & COA Transparency In the post-MoCRA USA regulatory environment, we maintain strict compliance with federal research reagent standards. Every batch includes a Certificate of Analysis (COA) confirming purity and identity via HPLC and Mass Spectrometry.

REGULATORY & COMPLIANCE STATEMENT (RUO)

FOR RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL APPLICATION.

Research Use Classification: This compound is supplied solely for in-vitro biochemical testing, cellular assay studies, and laboratory calibration. Documented research data refers strictly to surface-appearance metrics in controlled in-vitro models; no claims regarding physiological or therapeutic outcomes are made or implied.

Laboratory Handling Protocol: This reagent is a synthetic peptide reference compound. Researchers must wear appropriate PPE, including chemical-resistant gloves and eye protection, and follow institutional biosafety protocols.

Strict Prohibition Statement: Any intent to use this product for internal or external human bodily application is a strict violation of federal research reagent regulations and our Terms of Service. Purchase constitutes acknowledgment of RUO-only status.

Laboratory Handling Protocol: This reagent is a synthetic peptide reference compound. Researchers must wear appropriate personal protective equipment (PPE)—including chemical-resistant gloves and eye protection- during reconstitution and handling.

All laboratory procedures should follow institutional biosafety protocols applicable to synthetic peptide compounds. Please refer to the Safety Data Sheet(SDS) for CAS 868844-74-0 before initiating laboratory work to ensure compliance with safety standards.

Strict Prohibition Statement:

Any intent to use this product for internal or external human bodily application is a strict violation of applicable federal research reagent regulations and our Terms of Service. Purchase constitutes acknowledgment of RUO-only status.

Any marketing or distribution language implying therapeutic, diagnostic, cosmetic, or wellness outcomes is a violation of MoCRA provisions and applicable FDA regulatory boundaries governing research reagents.

Frequently Asked Questions

Q1: Is this product intended for human use?

No. Acetyl Octapeptide-3 is classified and supplied exclusively as a Research Use Only (RUO) laboratory reagent for institutional and qualified researchers.

Q2: How does SNAP-8 differ from Acetyl Hexapeptide-8 in laboratory research? It

is a structurally extended version (eight amino acids vs. six) studied for potential differences in SNARE complex binding characteristics and molecular stability (PMC7662462).

Q3: What is the primary delivery challenge in topical research?

The stratum corneum layer significantly limits the passive permeation of large hydrophilic peptides.

Q4: Does this compound have FDA approval?

No. It has not received FDA approval for any therapeutic or diagnostic indication and is supplied exclusively as a research-grade reagent.

Q5: What concentrations are utilized in laboratory research?

Published laboratory concentration assay protocols utilize standardized laboratory concentrations to investigate signaling modulation. Researchers are referred to the specific methodology sections of cited peer-reviewed literature for precise laboratory parameters and assay system requirements.

Q6: Are there reported safety observations in preclinical literature?

No significant adverse safety signals were described in controlled laboratory assay models at research-grade concentrations (2020–2026 documentation).

Q7: Is this product suitable for personal wellness or self-administration?

No. This product is strictly for qualified laboratory use; any purchase intent otherwise violates our Terms of Service.

Q8: Does the research literature describe complete pathway inhibition?

No. Published in-vitro data describes partial modulation of vesicle-fusion signaling pathways rather than complete pathway inhibition (PMC7662462).

Q9: What is the shelf life of the lyophilized reagent?

Sealed and stored at -20°C, it is stable for up to 24 months from manufacture, as specified in the COA.

Q10: Can this compound be used as a dietary supplement or cosmetic ingredient?

No. Use is limited to in-vitro biochemical research by qualified personnel in institutional laboratory environments.